Immune status characteristics of heifers at the age of 12 months when using a tissue biostimulator based on slaughterhouse tankage of antler deer industry

The article is concerned with immune status evaluation at replacement cattle aged 12 months when using a tissue biostimulator based on antler deer slaughterhouse tankage. The experiment on replacement young cattle took place at on-the-farm conditions of JSC “Uchkhoz “Prigorodnoe,” the Industrial District of Barnaul, Altai Territory. The researchers administered the tissue biostimulant to the experimental animals aged 1 to 12 months of rearing monthly with 30 days intervals at different doses according to the schedule: the first experimental group: aged 1 to 5 months – 2 ml per head, aged 6 to 11 months – 4 ml per head, aged 12 months – 8.0 ml per head; the second experimental group: aged 1 to 5 months – 3 ml per head, aged 6 to 11 months – 6 ml per head, at 12 months – 15.0 ml per head; the third experimental group: aged 1 to 5 months – 4 ml per head, aged 6 to 11 months – 8 ml per head, aged 12 months – 16.0 ml per head. Control animals were injected with normal saline: aged 1 to 5 months – 3 ml per head, aged 6 to 11 months – 6 ml per head, aged 12 months – 15 ml per head. The studies found that the optimal dose and tissue biostimulant dosing schedule, promoting the relative content of the tE-POK subpopulations by 5.0% (p ≤ 0.01), bE-POK by 4.9% (p ≤ 0.001), pE- ROC by 5.0% (p ≤ 0.05) EM-ROC by 3.1% (p ≤ 0.01), decreasing vE-ROC by 2.6% (p ≤ 0.05) and increasing in the absolute content of bEROC by 72.4% (p ≤ 0.05), respectively, are 3 ml per head for aged 1 to 5 months, 6 ml per head aged 6 to 11 months and 15.0 ml per head aged 12 months.

1. Alekseev A.D., Odegov E.S., Petrova O.G. Sovremennye vozmozhnosti immunomoduliruyushchey terapii v profilaktike ostrykh respiratornykh virusnykh infektsiy krupnogo rogatogo skota [Modern possibilities of immunomodulatory therapy in the prevention of acute respiratory viral infections in cattle]. Agrarniy vestnik Urala. 2017; 3 (157): 5–8. (In Rus.)

2. Andreeva A.V., Nikolaeva O.N. Dynamika morfologicheskikh pokazateley krovi pri korrektsii spetsificheskogo immuniteta [Dynamics of morphological blood parameters during correction of specific immunity]. Morfologiya. 2018; 153 (3): 20. (In Rus.)

3. Arilov A.N., Golembovskiy V.V. Ispol’zovanie immunno moduliruyushchego preparata “PIM” v skotovodstve [Use of the immuno-modulating drug PIM in cattle breeding]. Sbornik nauchnykh trudov severo-kavkazskogo nauchno-issledovatel’skogo instituta zhivotnovodstva. 2017; 6 (2): 68–73. (In Rus.)

4. Afanas’eva A.I., Sarychev V.A., Zhurko K.V. Vliyanie probiotika “Vetom 4.24” i sorbenta “Polisorb VP” na morfologicheskie i biokhimicheskie pokazateli krovi telyat kulundinskogo tipa krasnoy stepnoy porody [Effect of Vetom 4.24 probiotic and Polysorb VP sorbent on morphological and biochemical blood parameters of Kulunda red steppe calves]. Vestnik Altayskogo gosudarstvennogo agrarnogo universiteta. 2018; 5 (163): 106–112. (In Rus.)

5. Daricheva E.N., Ermolaev V.A. Tkanevaya terapiya v veterinarnoy meditsine [Tissue therapy in veterinary medicine]. Ul’yanovsk: UGSKHA, 2011: 168. (In Rus.)

6. Loretts O.G., Gorelik O.V., Belyaeva N.V. Osobennosti rosta i razvitiya telok pri kholodnom metode vyrashchivaniya [Features of heifer growth and development in the cold rearing method]. Agrarniy vestnik Urala. 2017; 6 (160): 9–15. (In Rus.)

7. Milostiviy R.V., Vysokos M.P., Tyupina N.V., Milostivaya D.F. Osobennosti stanovleniya prirodnoy rezistentnosti organizma telyat golshtinskoy porody v usloviyakh promyshlennogo kompleksa [Peculiarities of formation of natural resistance of Holstein calves under conditions of industrial complex]. Aktual’nye problemy intensivnogo razvitiya zhivotnovodstva. 2017; 20 (2): 85–90. (In Rus.)

8. Ovsyannikov A.P., Sunagatullin F.A., Khayrullin D.D. Vliyanie biologicheskogo stimulyatora po V.P. Filatovu, s dobavleniem mikroelementov na biokhimicheskiy sostav krovi telyat [Effect of biological stimulant according to V.P. Filatov, with the addition of trace elements on the biochemical composition of calf blood]. Uchenye zapiski Kazanskoy gosudarstvennoy akademii veterinarnoy meditsiny im. N.E. Baumana. 2017; 3: 112–114. (In Rus.)

9. Rubinskiy I.A., Petrova O.G. Immunnye stimulyatory v veterinarii [Immune stimulants in veterinary medicine]. Ul’yanovsk: UGSKHA. 2011: 168. (In Rus.)

10. Sozaeva D.I. Osnovnye mekhanizmy vzaimodeystviya nervnoy i immunnoy system [Basic mechanisms of interaction between the nervous and immune systems]. Kliniko-eksperimental’nye dannye. Kubanskiy nauchniy meditsinskiy vestnik. 2014; 3: 145–150. (In Rus.)

11. Sokolova E.S., Eremin S.P., Yashin I.V. Biokhimicheskiy gomeostaz u korov pod vliyaniem tkanevykh preparatov [Biochemical homeostasis in cows under the influence of tissue preparations]. Vestnik Nizhegorodskoy gosudarstvennoy sel’skokhozyaystvennoy akademii. 2013; 3: 441–443. (In Rus.)

12. Topuriya G.M., Topuriya L.Yu. Immunniy status krupnogo rogatogo skota pri primenenii gamavita [Immune status of cattle when using Gamavit]. Izvestiya Orenburgskogo gosudarstvennogo agrarnogo universiteta. 2011; 1 (29): 69–71. (In Rus.)

13. Trofimov A.V., Timoshenko V.N., Muzyka A.A., Pechenova M.A., Balueva N.A., Gurina D.V. Vliyanie preparata “Erakond” na povyshenie immunokompetentnykh svoystv moloziva korov i immunitet telyat [Effect of Erakond on improving the immunocompetent properties of cow colostrum and calf immunity]. Zootekhnicheskaya nauka Belorussii. 2009; 44 (1): 285–294. (In Rus.)

14. Kharitonova O.V., Kharitonov L.V., Velikanov V.I., Klyapnev A.V. Issledovaniya effektivnosti razlichnykh sposobov povysheniya kolostral’nogo immuniteta u novorozhdennykh telyat [Studies on the efficacy of different ways of improving colostral immunity in newborn calves]. Problemy biologii produktivnykh zhivotnykh. 2018; 2: 81–93. (In Rus.)

15. Hartenstein V., Giangrande A. Connecting the nervous and the immune systems in evolution. Communications Biology. 2018; 64: 1–5.

16. Li X., Su Y., Sun J., Yang Y. Chicken embryo extracts enhance spleen lymphocyte and peritoneal macrophages function. J Ethnopharmacol. 2012; 144 (2): 255–260.