izvestiiatimacadИзвестия Тимирязевской сельскохозяйственной академииIZVESTIYA OF TIMIRYAZEV AGRICULTURAL ACADEMY0021-342XФГБОУ ВО РГАУ-МСХА имени К.А. Тимирязева10.26897/0021-342X-2023-1-104-113izvestiiatimacad-392Research ArticleЗООТЕХНИЯ, БИОЛОГИЯ И ВЕТЕРИНАРНАЯ МЕДИЦИНАLIVESTOCK BREEDING, BIOLOGY AND VETERINARY MEDICINEТерапевтическая эффективность эстрофантина при псевдобеременности (гидрометре) у козTherapeutic potency of estrophanthin in pseudo-pregnancy (hydrometra) of goatsШатскийК. О.ShatskyK. O.

Шатский Кирилл Олегович, аспирант кафедры ветеринарной медицины

127550, г. Москва, ул. Тимирязевская, 49

тел.: (499) 977–17–82

Kirill O. Shatsky, post-graduate student of the Department of Veterinary Medicine

49 Timiryazevskaya Str., Moscow, 127434

phone: (499) 977–17–82

kirill199651@gmail.comДюльгерД. П.DyulgerG. P.

Дюльгер Георгий Петрович, д-р ветеринар. наук, заведующий кафедрой ветеринарной медицины

127550, г. Москва, ул. Тимирязевская, 49

тел.: (499) 977–17–82

Georgiy P. Dyulger, DSc (Vet), Head of the Department of Veterinary Medicine

49 Timiryazevskaya Str., Moscow, 127434

phone: (499) 977–17–82

dulger@rgau-msha.ruРоссийский государственный аграрный университет – МСХА имени К.А. ТимирязеваРоссияRussian State Agrarian University – Moscow Timiryazev Agricultural AcademyRussian Federation20231605202301104113Copyright © Шатский К.О., Дюльгер Д.П., 20232023Шатский К.О., Дюльгер Д.П.Shatsky K.O., Dyulger G.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://izvestiia.timacad.ru/jour/article/view/392

Цель исследований – провести сравнительную оценку терапевтической эффективности Эстрофантина®, препарата высокоактивного синтетического аналога простагландина Ф2 альфа (ПгФ2α) клопростенола, при его двукратном с перерывом 10 сут. внутримышечном ведении козам с гидрометрой в дозе 0,5 и 1 мл соответственно. Объектом исследований служили ремонтные козочки случного возраста (n=6) и лактирующие козы (n=37) зааненской породы, у которых при скрининговом ультразвуковом обследовании на беременность и бесплодие диагностировали ложную сукозность. По принципу аналогов животных разделили на две подопытные группы. Животным первой опытной группы (n=21) Эстрофантин ® вводили внутримышечно двукратно с перерывом 10 сут. в дозе 0,5 мл (125 мкг клопростенола), животным второй группы (n=22) – также внутримышечно двукратно с перерывом 10 сут., но в дозе 1 мл (250 мкг клопростенола). Результаты исследований показали высокую терапевтическую эффективность Эстрофантина ® при его двукратном с перерывом10 сут. внутримышечном применении козам с гидрометрой в дозе 1 мл. После введения первой дозы препарата полная экспульсия внутриматочной жидкости отмечена у 81,82% коз с гидроме- трой. По доле выздоровевших животных эффективность метода за полный курс лечения составила 100%, по показателю частоты возобновления половой цикличности и фертильности – 86,36 и 77,27% соответственно. При этом ни у одной из 5 (22,73%) признанных бесплодными коз после проведенного курса лечения не зарегистрировали рецидив гидрометры.

Установлено, что доза Эстрофантина®, равная 0,5 мл (125 мкг клопростенола), является недостаточно адекватной для терапии коз с гидрометрой. После первого введения указанной дозы полнаяэкспульсия внутриматочной жидкости наступает только у 52,38% животных. При использовании Эстрофантина® в минимальных терапевтических дозах (125 мкг клопростенола) эффективность простагландиновой терапии за полный курс лечения снижается по доле выздоровевших животных на 4,76%, по показателю восстановления половой цикличности – на 10,17%, по частоте наступления беременности – на 15,37%. При этом риск рецидива гидрометры составляет 5%.

The aim of the study was to carry out a comparative evaluation of the therapeutic potency of Estrophantine®, a drug of the highly active synthetic analog of prostaglandin F2 alpha (PgF2α) cloprostenol, when goats with hydrometer were twice injected intramuscularly with a 10-day interval in a dose of 0.5 and 1.0 ml, respectively. The objects of the study were breeding goats of breeding age (n=6) and lactating goats (n=37) of the Zaanen breed diagnosed with false pregnancy during screening ultrasound examination. The animals were divided into two experimental groups according to the analogy principle. The animals in the first experimental group (n=21) were twice injected intramuscularly with a 10-day interval in the dose of 0.5 ml (125 μg cloprostenol), and those in the second group (n=22) were also twice injected intramuscularly with with a 10-day interval, but in the dose of 1.0 ml (250 μg cloprostenol). The results of the study showed high therapeutic potency of Estrophantine® when goats with hydrometer were twice injected intramuscularly with with a 10-day interval in the dose of 1.0 ml. After the first dose of the preparation complete expulsion of intrauterine fluid was noted in 81.82% of goats with hydrometer. The effectiveness of the method for a complete course of treatment was 100% according to the percentage of cured animals, and 86.36% and 77.27% according to the frequency of renewal of sexual cycling and pregnancy rate, respectively. None of the 5 (22.73%) goats found to be infertile registered a relapse of hydrometra after treatment.

An Estrofantin® dose of 0.5 ml (125 μg cloprostenol) was found to be inadequate for treatment of goats with hydrometra. After the first dose, complete expulsion of intrauterine fluid was noted in only 52.38% of animals. When Estrophantine® is used at the lowest therapeutic dose (125 μg cloprostenol) the effectiveness of prostaglandin therapy over a full course of treatment is reduced by 4.76% in the proportion of cured animals, by 10.17% in the renewal of sexual cycling and by 15.37% in pregnancy rate. At the same time, the risk of relapse is 5%.

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The authors declare that there are no conflicts of interest present.