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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">izvestiiatimacad</journal-id><journal-title-group><journal-title xml:lang="ru">Известия Тимирязевской сельскохозяйственной академии</journal-title><trans-title-group xml:lang="en"><trans-title>IZVESTIYA OF TIMIRYAZEV AGRICULTURAL ACADEMY</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0021-342X</issn><publisher><publisher-name>ФГБОУ ВО РГАУ-МСХА имени К.А. Тимирязева</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.26897/0021-342X-2021-6-71-80</article-id><article-id custom-type="elpub" pub-id-type="custom">izvestiiatimacad-182</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЗООТЕХНИЯ, БИОЛОГИЯ И ВЕТЕРИНАРНАЯ МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LIVESTOCK BREEDING, BIOLOGY AND VETERINARY MEDICINE</subject></subj-group></article-categories><title-group><article-title>Морфо-биохимический скрининг при остром серозном мастите у овец</article-title><trans-title-group xml:lang="en"><trans-title>Morpho-biochemical screening for acute serous mastitis in sheep</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ватников</surname><given-names>Юрий Анатольевич</given-names></name><name name-style="western" xml:lang="en"><surname>Vatnikov</surname><given-names>Yu. A.</given-names></name></name-alternatives><email xlink:type="simple">vatnikov@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Руденко</surname><given-names>Павел Анатольевич</given-names></name><name name-style="western" xml:lang="en"><surname>Rudenko</surname><given-names>P. A.</given-names></name></name-alternatives><email xlink:type="simple">pavelrudenko76@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куликов</surname><given-names>Евгений Владимирович</given-names></name><name name-style="western" xml:lang="en"><surname>Kulikov</surname><given-names>E. V.</given-names></name></name-alternatives><email xlink:type="simple">eugeny1978@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юлдашбаев</surname><given-names>Юсупжан Артыкович</given-names></name><name name-style="western" xml:lang="en"><surname>Yuldashbaev</surname><given-names>Yu. A.</given-names></name></name-alternatives><email xlink:type="simple">zoo@rgau-msha.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карасев</surname><given-names>Евгений Анатольевич</given-names></name><name name-style="western" xml:lang="en"><surname>Karasev</surname><given-names>E. A.</given-names></name></name-alternatives><email xlink:type="simple">ekarasev@rgau-msha.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Колосов</surname><given-names>Юрий Анатольевич</given-names></name><name name-style="western" xml:lang="en"><surname>Kolosov</surname><given-names>Yu. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Безбородов</surname><given-names>Юрий Германович</given-names></name><name name-style="western" xml:lang="en"><surname>Bezborodov</surname><given-names>Yu. G.</given-names></name></name-alternatives><email xlink:type="simple">ubezborodov@rgau-msha.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский университет дружбы народов (РУДН)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>RUDN University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Российский университет дружбы народов (РУДН); ФГБУН «Филиал института биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук» (ФИБХ РАН)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>RUDN University; Branch of the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Российский государственный аграрный университет - МСХА имени К.А. Тимирязева</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian State Agrarian University - Moscow Timiryazev Agricultural Academy</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Донской государственный аграрный университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Don State Agrarian University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>17</day><month>11</month><year>2022</year></pub-date><volume>0</volume><issue>6</issue><fpage>71</fpage><lpage>80</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ватников Ю.А., Руденко П.А., Куликов Е.В., Юлдашбаев Ю.А., Карасев Е.А., Колосов Ю.А., Безбородов Ю.Г., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Ватников Ю.А., Руденко П.А., Куликов Е.В., Юлдашбаев Ю.А., Карасев Е.А., Колосов Ю.А., Безбородов Ю.Г.</copyright-holder><copyright-holder xml:lang="en">Vatnikov Y.A., Rudenko P.A., Kulikov E.V., Yuldashbaev Y.A., Karasev E.A., Kolosov Y.A., Bezborodov Y.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://izvestiia.timacad.ru/jour/article/view/182">https://izvestiia.timacad.ru/jour/article/view/182</self-uri><abstract><p>В современных условиях решение проблемы диагностики, терапии и профилактики данного заболевания остро необходимо. В статье приведены морфологические и биохимические показатели крови овец при остром серозном мастите. Исследования проведены на поголовье овец (956 гол.) Комплекс клинико-лабораторных исследований выполнен на 12 овцах сальской породы с признаками острого серозного мастита, в возрасте 2-3 года. Контролем служили клинически здоровые овцы в возрасте 2-3 года. При клиническом исследовании овец обращали внимание на общее состояние, температуру тела, частоту сердечных сокращений, дыхание и движение рубца за 2 мин. Показано, что при серозном мастите отмечается повышение температуры тела до 40,5-40,9 °С, частоты пульса до 95ударов в 1 мин., а дыхания - до 40 дыхательных движений в 1 мин. При этом частота сокращений рубца составляла 3-6 раз за 2 мин. При клиническом осмотре пораженная половина вымени овцы увеличена в 3-4 раза в объеме, уплотнена, кожа напряжена, сосок молочной железы незначительно увеличен и вялый. Надвыменный лимфатический узел увеличен в объеме в 1,5-2 раза, на пальпацию больные овцы реагировали болезненно. Молоко из пораженной доли в начале воспаления имело белый цвет, а при переходе болезни в более тяжелую форму становилось водянистым с примесью крови. Как правило, серозный мастит протекал остро. Также наблюдали частичную потерю аппетита. Установлено, что острый серозный мастит у овец клинически проявляется угнетением, субфебрильным или фебрильным повышением температуры тела, умеренным тахипноэ и тахикардией. В крови овец при остром серозном мастите происходит достоверное снижение количества эритроцитов и гемоглобина и развивается выраженный нейтрофильный лейкоцитоз с простым сдвигом регенераторного ядра влево на фоне умеренной эозинофилии. В сыворотке крови овец, больных острым маститом, выявляют диспротеинемию, которая характеризуется умеренным снижением концентрации альбумина и значительным повышением содержания альфа-глобулинов. В сывортке крови у больных овец также достоверно снижается концентрация железа и повышается содержание меди.</p></abstract><trans-abstract xml:lang="en"><p>Despite significant achievements in the agricultural sector, the problem of mastitis in sheep continues to be one of the most relevant for veterinary science and practice. Therefore, in current conditions, the solution of diagnosis, therapy, and prevention of this disease is urgently needed. The article presents morphological and biochemical parameters of sheep blood in acute serous mastitis. The research was at “Belozernoe” of the Salsk district of the Rostov region, with a total number of sheep of 956 heads. The complex of clinical and laboratory studies was performed on 12 sheep of the Sokolskaya breed (at the age of 2-3 years), with signs of acute serous mastitis. The control group consisted of clinically healthy sheep aged 2-3 years. In a clinical study of sheep, the researchers focused on the general condition, body temperature, heart rate, respiration, and scar movement in two minutes. The study has shown that in serous mastitis, there is an increase in body temperature to 40.5-40.9°C, pulse rate to 95 beats per minute, and respiration - up to 40 respiratory movements per minute. The frequency of scar contractions was 3-6 times in two minutes. During the clinical examination, the affected half of the sheep’s udder was enlarged 3-4 times in volume, compacted, the skin is tense, and the breast nipple is slightly enlarged and flaccid. The supravyminal lymph node enlarged in volume by 1.5-2 times, and the sick sheep reacted painfully to palpation. At the beginning of the inflammation, milk from the affected lobe had a white color. When the disease passed into a more severe form, it became watery with an admixture of blood. As a rule, severe mastitis was acute. There was a partial loss of appetite. The researchers established that acute serous mastitis in sheep is clinically manifested by depression, subfebrile or febrile increase in body temperature, moderate tachypnea, and tachycardia. In the blood of sheep with acute serous mastitis, there is a significant decrease in the number of red blood cells and hemoglobin. A pronounced neutrophilic leukocytosis develops with a simple shift of the regenerative nucleus to the left against the background of moderate eosinophilia. In the blood serum of sheep with acute mastitis, dysproteinemia is detected, characterized by a moderate decrease in albumin concentration and a significant increase in the content of alpha-globulins. In the blood serum of sick sheep, the concentration of iron also significantly decreases, and the content of copper increases.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>воспаление</kwd><kwd>мастит</kwd><kwd>биохимические анализы</kwd><kwd>перекисное окисление липидов</kwd><kwd>антиоксидантная система</kwd><kwd>овцы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>inflammation</kwd><kwd>mastitis</kwd><kwd>biochemical analytes</kwd><kwd>lipid peroxidation</kwd><kwd>antioxidant system</kwd><kwd>sheep</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Achek R. Short communication: Diversity of staphylococci isolated from sheep mastitis in northern Algeria / R. Achek, H. El-Adawy H. Hotzel, H. Tomaso, R. Ehricht, T.M. Hamdi, O. Azzi, S. Monecke // J. Dairy Sci., 2020. - 103 (1). - Р 890-897.</mixed-citation><mixed-citation xml:lang="en">Achek R. Short communication: Diversity of staphylococci isolated from sheep mastitis in northern Algeria / R. Achek, H. El-Adawy H. Hotzel, H. Tomaso, R. Ehricht, T.M. Hamdi, O. Azzi, S. Monecke // J. Dairy Sci., 2020. - 103 (1). - Р 890-897.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Banos G. The genomic architecture of mastitis resistance in dairy sheep / G. Banos, G. Bramis, S.J. Bush, E.L. Clark M.E.B. McCulloch J. Smith, G. Schulze, G. Arsenos, D.A. Hume, A. Psifidi // BMC Genomics, 2017. - 18 (1). - Р. 624.</mixed-citation><mixed-citation xml:lang="en">Banos G. The genomic architecture of mastitis resistance in dairy sheep / G. Banos, G. Bramis, S.J. Bush, E.L. Clark M.E.B. McCulloch J. Smith, G. Schulze, G. Arsenos, D.A. Hume, A. Psifidi // BMC Genomics, 2017. - 18 (1). - Р. 624.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Fthenakis G.C. Editorial: Research on mastitis in sheep / G.C. Fthenakis // J. Dairy Res., 2019. - 86 (3). - Р. 253.</mixed-citation><mixed-citation xml:lang="en">Fthenakis G.C. Editorial: Research on mastitis in sheep / G.C. Fthenakis // J. Dairy Res., 2019. - 86 (3). - Р. 253.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Gelasakis A.I. Mastitis in sheep - The last 10 years and the future of research / A.I. Gelasakis, V.S. Mavrogianni, I.G. Petridis, N.G. Vasileiou, G.C. Fthenakis // Vet. Microbiol., 2015. - 181 (1-2). - Р. 136-146.</mixed-citation><mixed-citation xml:lang="en">Gelasakis A.I. Mastitis in sheep - The last 10 years and the future of research / A.I. Gelasakis, V.S. Mavrogianni, I.G. Petridis, N.G. Vasileiou, G.C. Fthenakis // Vet. Microbiol., 2015. - 181 (1-2). - Р. 136-146.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Mavrogianni V.S. Principles of mastitis treatment in sheep and goats / V.S. Mavrogianni, P.I. Menzies, I.A. Fragkou, G.C. Fthenakis // Vet. Clin. North. Am. Food Anim. Pract., 2011. - 27 (1). - Р. 115-120.</mixed-citation><mixed-citation xml:lang="en">Mavrogianni V.S. Principles of mastitis treatment in sheep and goats / V.S. Mavrogianni, P.I. Menzies, I.A. Fragkou, G.C. Fthenakis // Vet. Clin. North. Am. Food Anim. Pract., 2011. - 27 (1). - Р. 115-120.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">McLaren A. New mastitis phenotypes suitable for genomic selection in meat sheep and their genetic relationships with udder conformation and lamb live weights / A. McLaren K. Kaseja, J. Yates, S. Mucha, N.R. Lambe, J. Conington // Animal, 2018. - 12 (12). -Р. 2470-2479.</mixed-citation><mixed-citation xml:lang="en">McLaren A. New mastitis phenotypes suitable for genomic selection in meat sheep and their genetic relationships with udder conformation and lamb live weights / A. McLaren K. Kaseja, J. Yates, S. Mucha, N.R. Lambe, J. Conington // Animal, 2018. - 12 (12). -Р. 2470-2479.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Palikov V.A. A novel view of the problem of Osteoarthritis in experimental rat model / V.A. Palikov, Y.A. Palikova, N.A. Borozdina, E.N. Nesmeyanova, P.A. Rudenko, V.A. Kazakov, E.A. Kalabina, M.V. Bukatin, T.Y. Zharmukhamedova, O.N. Khokhlova, I.A. Dyachenko // Research Results in Pharmacology, 2020. - 6 (2). - Р. 19-25.</mixed-citation><mixed-citation xml:lang="en">Palikov V.A. A novel view of the problem of Osteoarthritis in experimental rat model / V.A. Palikov, Y.A. Palikova, N.A. Borozdina, E.N. Nesmeyanova, P.A. Rudenko, V.A. Kazakov, E.A. Kalabina, M.V. Bukatin, T.Y. Zharmukhamedova, O.N. Khokhlova, I.A. Dyachenko // Research Results in Pharmacology, 2020. - 6 (2). - Р. 19-25.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Rudenko P.A. Technological process of integrated probiotics sorption drugs «Dilaksil» and «Sorbelact» / P.A. Rudenko, A.N. Murashev // Russian Journal of Biopharmaceuticals, 2017. - 9 (3). - Р. 49-54.</mixed-citation><mixed-citation xml:lang="en">Rudenko P.A. Technological process of integrated probiotics sorption drugs «Dilaksil» and «Sorbelact» / P.A. Rudenko, A.N. Murashev // Russian Journal of Biopharmaceuticals, 2017. - 9 (3). - Р. 49-54.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Rudenko P. Biocoenotic Diagnostics of Unfavorable Factors in the Cows Infection of Farms in the Moscow Region / P. Rudenko, V. Rudenko, Y. Vatnikov, A. Rudenko, E. Kulikov, N. Sachivkina, E. Sotnikova, N. Sturov, E. Rusanova, T. Mansur, S. Vyalov, N. Sakhno, S. Drukovsky // Systematic Reviews in Pharmacy, 2020. - 11 (5). - Р. 347-357.</mixed-citation><mixed-citation xml:lang="en">Rudenko P. Biocoenotic Diagnostics of Unfavorable Factors in the Cows Infection of Farms in the Moscow Region / P. Rudenko, V. Rudenko, Y. Vatnikov, A. Rudenko, E. Kulikov, N. Sachivkina, E. Sotnikova, N. Sturov, E. Rusanova, T. Mansur, S. Vyalov, N. Sakhno, S. Drukovsky // Systematic Reviews in Pharmacy, 2020. - 11 (5). - Р. 347-357.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Rudenko P. Role of microorganisms isolated from cows with mastitis in Moscow region in biofilm formation / P. Rudenko, N. Sachivkina, Y. Vatnikov, S. Shabunin, S. Engashev, S. Kontsevaya, A. Karamyan, D. Bokov, O. Kuznetsova, E. Vasilieva // Veterinary World, 2021. - 14 (1). - Р. 40-48.</mixed-citation><mixed-citation xml:lang="en">Rudenko P. Role of microorganisms isolated from cows with mastitis in Moscow region in biofilm formation / P. Rudenko, N. Sachivkina, Y. Vatnikov, S. Shabunin, S. Engashev, S. Kontsevaya, A. Karamyan, D. Bokov, O. Kuznetsova, E. Vasilieva // Veterinary World, 2021. - 14 (1). - Р. 40-48.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Smolentsev S.Yu. Influence of para-aminobenzoic acid on young cattle / S.Yu. Smolentsev A.H. Volkov, E.K. Papunidi, L.F. Yakupova, R.N. Fayzrakhmanov, I. Bouadila, A.A. Rudenko, P.A. Rudenko // International Journal of Research in Pharmaceutical Sciences, 2020. - 11 (2). - Р. 1481-1485.</mixed-citation><mixed-citation xml:lang="en">Smolentsev S.Yu. Influence of para-aminobenzoic acid on young cattle / S.Yu. Smolentsev A.H. Volkov, E.K. Papunidi, L.F. Yakupova, R.N. Fayzrakhmanov, I. Bouadila, A.A. Rudenko, P.A. Rudenko // International Journal of Research in Pharmaceutical Sciences, 2020. - 11 (2). - Р. 1481-1485.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Vasileiou N.G.C. Extensive countrywide field investigation of subclinical mastitis in sheep in Greece / N.G.C. Vasileiou P.J. Cripps, K.S. Ioannidi, D.C. Chatzopoulos, D.A. Gougoulis, S. Sarrou, D.C. Orfanou, A.P. Politis, T.C. Gonzalez-Valerio S. Argyros, V.S. Mavrogianni, E. Petinaki, G.C. Fthenakis // J. Dairy Sci., 2018. - 101 (8). - Р. 7297-7310.</mixed-citation><mixed-citation xml:lang="en">Vasileiou N.G.C. Extensive countrywide field investigation of subclinical mastitis in sheep in Greece / N.G.C. Vasileiou P.J. Cripps, K.S. Ioannidi, D.C. Chatzopoulos, D.A. Gougoulis, S. Sarrou, D.C. Orfanou, A.P. Politis, T.C. Gonzalez-Valerio S. Argyros, V.S. Mavrogianni, E. Petinaki, G.C. Fthenakis // J. Dairy Sci., 2018. - 101 (8). - Р. 7297-7310.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Vasileiou N.G.C. Role of staphylococci in mastitis in sheep / N.G.C. Vasileiou D.C. Chatzopoulos, S. Sarrou, I.A. Fragkou, A.I. Katsafadou, V.S. Mavrogianni, E. Petinaki, G.C. Fthenakis // J. Dairy Res., 2019. - 86 (3). - Р. 254-266.</mixed-citation><mixed-citation xml:lang="en">Vasileiou N.G.C. Role of staphylococci in mastitis in sheep / N.G.C. Vasileiou D.C. Chatzopoulos, S. Sarrou, I.A. Fragkou, A.I. Katsafadou, V.S. Mavrogianni, E. Petinaki, G.C. Fthenakis // J. Dairy Res., 2019. - 86 (3). - Р. 254-266.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Vasileiou N.G.C. Slime-producing staphylococci as causal agents of subclinical mastitis in sheep / N.G.C. Vasileiou D.C. Chatzopoulos, D.A. Gougoulis, S. Sarrou, A.I. Katsafadou, V. Spyrou, V.S. Mavrogianni, E. Petinaki, G.C. Fthenakis // Vet. Microbiol., 2018. - 224. - Р. 93-99.</mixed-citation><mixed-citation xml:lang="en">Vasileiou N.G.C. Slime-producing staphylococci as causal agents of subclinical mastitis in sheep / N.G.C. Vasileiou D.C. Chatzopoulos, D.A. Gougoulis, S. Sarrou, A.I. Katsafadou, V. Spyrou, V.S. Mavrogianni, E. Petinaki, G.C. Fthenakis // Vet. Microbiol., 2018. - 224. - Р. 93-99.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Vasileiou N.G.C. Evaluation of efficacy of a biofilm-embedded bacteria-based vaccine against staphylococcal mastitis in sheep-A randomized, placebo-controlled field study / N.G.C. Vasileiou D.C. Chatzopoulos, P.J. Cripps, K.S. Ioannidi, D.A. Gougoulis, T.M. Chouzouris, D.T. Lianou, T.C. Gonzalez-Valerio R.G. Vallverdu, S. Argyros, M. Cesio, I. Font, V.S. Mavrogianni, E. Petinaki, G.C. Fthenakis // J. Dairy Sci., 2019. -102 (10). - Р. 9328-9344.</mixed-citation><mixed-citation xml:lang="en">Vasileiou N.G.C. Evaluation of efficacy of a biofilm-embedded bacteria-based vaccine against staphylococcal mastitis in sheep-A randomized, placebo-controlled field study / N.G.C. Vasileiou D.C. Chatzopoulos, P.J. Cripps, K.S. Ioannidi, D.A. Gougoulis, T.M. Chouzouris, D.T. Lianou, T.C. Gonzalez-Valerio R.G. Vallverdu, S. Argyros, M. Cesio, I. Font, V.S. Mavrogianni, E. Petinaki, G.C. Fthenakis // J. Dairy Sci., 2019. -102 (10). - Р. 9328-9344.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Vasileiou N.G.C. Predisposing factors for bacterial mastitis in ewes / N.G.C. Vasileiou V.S. Mavrogianni, E. Petinaki, G.C. Fthenakis // Reprod. Domest. Anim., 2019. -54 (10). - Р 1424-1431.</mixed-citation><mixed-citation xml:lang="en">Vasileiou N.G.C. Predisposing factors for bacterial mastitis in ewes / N.G.C. Vasileiou V.S. Mavrogianni, E. Petinaki, G.C. Fthenakis // Reprod. Domest. Anim., 2019. -54 (10). - Р 1424-1431.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Vasileiou N.G. Association of subclinical mastitis prevalence with sheep breeds in Greece / N.G. Vasileiou, D.A. Gougoulis, V. Riggio, K.S. Ioannidi, D.C. Chatzopoulos, V.S. Mavrogianni, E. Petinaki, G.C. Fthenakis // J. Dairy Res., 2018. - 85 (3). - Р. 317-320.</mixed-citation><mixed-citation xml:lang="en">Vasileiou N.G. Association of subclinical mastitis prevalence with sheep breeds in Greece / N.G. Vasileiou, D.A. Gougoulis, V. Riggio, K.S. Ioannidi, D.C. Chatzopoulos, V.S. Mavrogianni, E. Petinaki, G.C. Fthenakis // J. Dairy Res., 2018. - 85 (3). - Р. 317-320.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Vatnikov Yu. Research on the antibacterial and antimycotic effect of the phytopreparation Farnesol on biofilm-forming microorganisms in veterinary medicine / Yu. Vatnikov I. Donnik, E. Kulikov, A. Karamyan, N. Sachivkina, P. Rudenko, A. Tumanyan, N. Khairova, E. Romanova, R. Gurina, E. Sotnikova, I. Bondareva // International Journal of Pharmaceutical Research, 2020. - 12 (S. 2). - Р. 1481-1492.</mixed-citation><mixed-citation xml:lang="en">Vatnikov Yu. Research on the antibacterial and antimycotic effect of the phytopreparation Farnesol on biofilm-forming microorganisms in veterinary medicine / Yu. Vatnikov I. Donnik, E. Kulikov, A. Karamyan, N. Sachivkina, P. Rudenko, A. Tumanyan, N. Khairova, E. Romanova, R. Gurina, E. Sotnikova, I. Bondareva // International Journal of Pharmaceutical Research, 2020. - 12 (S. 2). - Р. 1481-1492.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Vatnikov Yu. Effectiveness of biologically active substances from Hypericum Perforatum L. in the complex treatment of purulent wounds / Yu. Vatnikov S. Shabunin, E. Kulikov, A. Karamyan, E. Lenchenko, N. Sachivkina, N. Bobkova, D. Bobkov, V. Zhilkina, A. Tokar, M. Shopinskaya, P. Rudenko // International Journal of Pharmaceutical Research, 2020. - 12 (4). - Р 1108-1117.</mixed-citation><mixed-citation xml:lang="en">Vatnikov Yu. Effectiveness of biologically active substances from Hypericum Perforatum L. in the complex treatment of purulent wounds / Yu. Vatnikov S. Shabunin, E. Kulikov, A. Karamyan, E. Lenchenko, N. Sachivkina, N. Bobkova, D. Bobkov, V. Zhilkina, A. Tokar, M. Shopinskaya, P. Rudenko // International Journal of Pharmaceutical Research, 2020. - 12 (4). - Р 1108-1117.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Vatnikov Yu. Antimicrobial activity of Hypericum Perforatum L. / Yu. Vatnikov S. Shabunin, A. Karamyan, E. Kulikov, N. Sachivkina, V. Stepanishin, E. Vasilieva, N. Bobkova, V. Lucay, V. Avdotin, A. Zenchenkova, P. Rudenko, A. Rudenko // International Journal of Pharmaceutical Research, 2020. - 12 (S. 1). - Р. 723-730.</mixed-citation><mixed-citation xml:lang="en">Vatnikov Yu. Antimicrobial activity of Hypericum Perforatum L. / Yu. Vatnikov S. Shabunin, A. Karamyan, E. Kulikov, N. Sachivkina, V. Stepanishin, E. Vasilieva, N. Bobkova, V. Lucay, V. Avdotin, A. Zenchenkova, P. Rudenko, A. Rudenko // International Journal of Pharmaceutical Research, 2020. - 12 (S. 1). - Р. 723-730.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
