izvestiiatimacadИзвестия Тимирязевской сельскохозяйственной академииIZVESTIYA OF TIMIRYAZEV AGRICULTURAL ACADEMY0021-342XФГБОУ ВО РГАУ-МСХА имени К.А. Тимирязеваizvestiiatimacad-1011Research ArticleЗООТЕХНИЯ, БИОЛОГИЯ И ВЕТЕРИНАРНАЯ МЕДИЦИНАLIVESTOCK BREEDING, BIOLOGY AND VETERINARY MEDICINEРешения для здоровья кишечника – новое направление в кормлении моногастричных животных (обзор)Solutions for intestinal health: a new direction in feeding monogastric animals (review)https://orcid.org/0000-0002-6776-0835БуряковН. П.BuryakovN. P.

Николай Петрович Буряков, д-р биол. наук, профессор, заведующий кафедрой кормления животных

127550, г. Москва, ул. Тимирязевская, 49

Nikolay P. Buryakov, DSc (Bio), Professor, Head of the Department of Animal Feeding

49 Timiryazevskaya St., Moscow, 127550

n.buryakov@rgau-msha.ruhttps://orcid.org/0009-0001-6726-5965МенбергВ. В.MenbergV. V.

Менберг Виктор Викторович, аспирант кафедры кормления животных

127550, г. Москва, ул. Тимирязевская, 49

Viktor V. Menberg, postgraduate student of the Department of Animal Feeding

49 Timiryazevskaya St., Moscow, 127550

viktor283www@mail.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Российский государственный аграрный университет – МСХА имени К.А.ТимирязеваРоссияRussian State Agrarian University – Moscow Timiryazev Agricultural AcademyRussian Federation20251307202503115138Copyright © Буряков Н.П., Менберг В.В., 20252025Буряков Н.П., Менберг В.В.Buryakov N.P., Menberg V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://izvestiia.timacad.ru/jour/article/view/1011

Генетический потенциал моногастричных животных можно реализовать только в результате слаженной работы желудочно-кишечного тракта, в котором происходит не только переваривание и всасывание компонентов рациона, но и обеспечение защиты организма от вредной микрофлоры. На функционирование кишечника ежедневно требуется до 40% протеина и энергии суточного количества комбикорма, так как в организме животных наблюдают быстрый оборот и смену энтероцитов, которые обновляются через каждые три дня. В статье рассмотрены актуальные аспекты использования пробиотиков, пребиотиков и комплексных препаратов на основе масляной кислоты в современных условиях промышленного свиноводства и птицеводства. Изучено действие пробиотиков различного состава на микрофлору желудочно-кишечного тракта моногастричных животных. Показано влияние кормовых добавок на повышение резистентности животных к заболеваниям кишечника путем ингибирования колонизации кишечными патогенами, повышения иммунитета, доступности питательных веществ рациона для птицы и свиней. Проведен детальный анализ механизма действия масляной кислоты в чистом виде, а также ее защищенных форм: бутиратов и триглицеридов. Описаны преимущества и недостатки бутирата кальция и натрия, используемых в качестве инструментов для здоровья кишечника.

Realizing the genetic potential of monogastric animals depends on a well-functioning gastrointestinal tract, which not only digests and absorbs nutrients but also protects against harmful microflora. This intestinal function is energetically expensive, requiring up to 40% of daily protein and energy intake to support rapid enterocyte turnover – these cells are replaced approximately every three days. This article reviews current perspectives on using probiotics, prebiotics, and butyric acid-based complexes in modern industrial pig and poultry farming. Studies examining the effects of probiotics with varying compositions on the gastrointestinal microflora of monogastric animals are discussed. Furthermore, the article highlights how these feed additives can enhance animal resistance to intestinal diseases by inhibiting pathogen colonization, boosting immunity, and improving nutrient availability in poultry and pigs.

пробиотикиадаптивные свойстваиммунитетрезистентностьмананоолигосахаридыпребиотикиподкислителиконверсия кормаProbioticsadaptive propertiesimmunityresistancemannooligosaccharidesprebioticsacidifiersfeed conversionРабота выполнена за счет средств Программы развития университета в рамках Программы стратегического академического лидерства «Приоритет-2030».The work was supported by funds from the University Development Program within the framework of the Strategic Academic Leadership Program “Priority 2030”.ReferencesБуяров А.В., Буяров В.С. Животноводство и птицеводство России: состояние, тенденции и перспективы развития в современных экономических условиях // Вестник Воронежского государственного аграрного университета. 2022. Т. 15, № 4 (75). С. 108-123. https://doi.org/10.53914/issn2071-2243_2022_4_108Buyarov A.V., Buyarov V.S. Animal husbandry and poultry farming in Russia: current state and development trends in modern economic conditions. Vestnik of Voronezh State Agrarian University. 2022;15(4(75)):108-123. (In Russ.) https://doi.org/10.53914/issn2071-2243_2022_4_108Зорина Е.Г. Проблемы и перспективы продовольственного обеспечения в условиях санкций // IV Международная научно-практическая конференция «Молодежная наука – развитию агропромышленного комплекса». Курск: Курский государственный аграрный университет имени И.И. Иванова, 2024. С. 190-197.Zorina E.G. Problems and prospects of food security under sanctions. IV Mezhdunarodnaya nauchno-prakticheskaya konferentsiya studentov, aspirantov i molodykh uchenykh ‘Molodezhnaya nauka – razvitiyu agropromyshlennogo kompleksa’. November 15, 2022. Kursk, Russia: Kursk State Agricultural Academy named after I.I. Ivanov, 2024:190-197. (In Russ.)Giraldo P.A., Shinozuka H., Spangenberg G.C. et al. Safety Assessment of Genetically Modified Feed: Is There Any Difference From Food? Front. Plant Sci. 2019;10:1592. https://doi.org/10.3389/fpls.2019.01592Giraldo P.A., Shinozuka H., Spangenberg G.C. et al. Safety Assessment of Genetically Modified Feed: Is There Any Difference From Food? Front. Plant Sci. 2019;10:1592. https://doi.org/10.3389/fpls.2019.01592Ковалев Ю. Развитие свиноводства: впереди новый этап // Животноводство России. 2024. № 2. С. 22-24. EDN: LIIMMWKovalyov Yu. Pig production development: a new stage ahead. Zhivotnovodstvo Rossii. 2024;(2):22-24. (In Russ.)Hardy H., Harris J., Lyon E. et al. Probiotics, prebiotics and immunomodulation of gut mucosal defences: homeostasis and immunopathology. Nutrients. 2013;5:1869-1912.Hardy H., Harris J., Lyon E., Beal J., Foey A.D. Probiotics, prebiotics and immunomodulation of gut mucosal defences: homeostasis and immunopathology. Nutrients. 2013;5:1869-1912.Алешин Д.Е. Продукты биотехнологической промышленности в кормлении животных: пробиотики, пребиотики, симбиотики, синбиотики и постбиотики // Фундаментальная и прикладная наука: состояние и тенденции развития. Петрозаводск: Новая Наука, 2024. С. 296-343. EDN: ZMHCPMAleshin D.E. Biotechnological industry products in animal feeding: probiotics, prebiotics, symbiotics, synbiotics and postbiotics. In: Abdullazyanov E.Yu., Akanova A.N., Akramov B.Sh., Aleshin D.E. et al. Fundamental and applied science: status and development trends: a monograph. Petrozavodsk, Russia: Mezhdunarodniy tsentr nauchnogo partnerstva “Novaya Nauka” (IP Ivanovskaya I.I.), 2024:296-343. (In Russ.)Kosolapova V.G., Buryakov N.P., Aleshin D.E. et al. Scientific and economic justification of application of symbiotic polycomponent fodder additive in feeding high productive cows. IOP Conf. Ser.: Earth Environ. Sci. 2021;901:012026. https://doi.org/10.1088/1755-1315/901/1/012026Kosolapova V.G., Buryakov N.P., Aleshin D.E. et al. Scientific and economic justification of application ofsymbiotic polycomponent fodder additive in feeding high productive cows. IOP Conf. Ser.: Earth Environ. Sci. 2021;901:012026. https://doi.org/10.1088/1755-1315/901/1/012026Khadija A.A. The synergistic effects of probiotic microorganisms on the microbial production of butyrate in vitro. McNair Scholars Research Journal. 2009;2(1):103-114.Khadija A.A. The synergistic effects of probiotic microorganisms on the microbial production of butyrate in vitro. McNair Scholars Research Journal. 2009;2(1):103-114.Bolton W., Dewar W.A. The digestibility of acetic, propionic and butyric acids by the fowl. British Poultry Science. 1965;6(2):103-105.Bolton W., Dewar W.A. The digestibility of acetic, propionic and butyric acids by the fowl. British Poultry Science. 1965;6(2):103-105.Afonso E.R., Parazzi L.J., Marino C.T. et al. Probiotics association in the suckling and nursery in piglets challenged with Salmonella typhimurium. Braz Arch Biol Technol. 2013;56:249-258. http://doi.org/10.1590/S1516-89132013000200010Afonso E.R., Parazzi L.J., Marino C.T. et al. Probiotics association in the suckling and nursery in piglets challenged with Salmonella typhimurium. Braz Arch Biol Technol. 2013;56:249-258. http://doi.org/10.1590/S1516-89132013000200010Ahmadifar E., Dawood M.A., Moghadam M.S. et al. The effect of Pediococcus acidilactici MA 18/5 M on immune responses and mRNA levels of growth, antioxidant and immune-related genes in zebrafish (Danio rerio). Aquaculture Rep. 2020;17:100374. https://doi.org/10.1016/j.aqrep.2020.100374Ahmadifar E., Dawood M.A., Moghadam M.S. et al. The effect of Pediococcus acidilactici MA 18/5 M on immune responses and mRNA levels of growth, antioxidant and immune-related genes in zebrafish (Danio rerio). Aquaculture Rep. 2020;17:100374. https://doi.org/10.1016/j.aqrep.2020.100374Ahmed S., Hoon J., Hong-Seok M., Chul-Ju Y. Evaluation of Lactobacillus and Bacillus-based probiotics as alternatives to antibiotics in enteric microbial challenged weaned piglets. Afr. J. Microbiol. Res. 2014;8(1):96-104. http://doi.org/10.5897/AJMR2013.6355Ahmed S., Hoon J., Hong-Seok M., Chul-Ju Y. Evaluation of Lactobacillus and Bacillus-based probiotics as alternatives to antibiotics in enteric microbial challenged weaned piglets. Afr. J. Microbiol. Res. 2014;8(1):96-104. http://doi.org/10.5897/AJMR2013.6355Baker A.A., Davis E., Spencer J.D. et al. The effect of a Bacillus-based direct-fed microbial supplemented to sows on the gastrointestinal microbiota of their neonatal piglets. J. Animal Sci. 2013;91(7):3390-3399. http://doi.org/10.2527/jas.2012-5821Baker A.A., Davis E., Spencer J.D. et al. The effect of a Bacillus-based direct-fed microbial supplemented to sows on the gastrointestinal microbiota of their neonatal piglets. J. Animal Sci. 2013;91(7):3390-3399. http://doi.org/10.2527/jas.2012-5821Barba-Vidal E., Castillejos L., Roll V.F. et al. The probiotic combination of Bifidobacterium longum subsp. Infantis CECT 7210 and Bifidobacterium animalis subsp. Lactis BPL6 reduces pathogen loads and improves gut health of weaned piglets orally challenged with Salmonella Typhimurium. Front Microbiol. 2017;8:1570. http://doi.org/10.3389/fmicb.2017.01570Barba-Vidal E., Castillejos L., Roll V.F. et al. The probiotic combination of Bifidobacterium longum subsp. Infantis CECT 7210 and Bifidobacterium animalis subsp. Lactis BPL6 reduces pathogen loads and improves gut health of weaned piglets orally challenged with Salmonella Typhimurium. Front Microbiol. 2017;8:1570. http://doi.org/10.3389/fmicb.2017.01570Ding H., Zhao X., Azad M.A.K. et al. Dietary supplementation with Bacillus subtilis and xylo-oligosaccharides improves growth performance and intestinal morphology and alters intestinal microbiota and metabolites in weaned piglets. Food Funct. 2021;12(58):5837-5849. https://doi.org/10.1039/d1fo00208bDing H., Zhao X., Azad M.A.K. et al. Dietary supplementation with Bacillus subtilis and xylo-oligosaccharides improves growth performance and intestinal morphology and alters intestinal microbiota and metabolites in weaned piglets. Food Funct. 2021;12(58):5837-5849. https://doi.org/10.1039/d1fo00208bChen Y., Xie Y., Zhong R. et al. Effects of xylo-oligosaccharides on growth and gut microbiota as potential replacements for antibiotic in weaning piglets. Front. Microbiol. 2021;12:641172. https://doi.org/10.3389/fmicb.2021.641172Chen Y., Xie Y., Zhong R. et al. Effects of xylo-oligosaccharides on growth and gut microbiota as potential replacements for antibiotic in weaning piglets. Front. Microbiol. 2021;12:641172. https://doi.org/10.3389/fmicb.2021.641172Kherade M., Solanke S., Tawar M., Wankhede S. Fructooligosaccharides: A comprehensive review. J. Ayu. Herb Med. 2021;7(3):193-200. https://doi.org/10.31254/jahm.2021.7305Kherade M., Solanke S., Tawar M., Wankhede S. Fructooligosaccharides: A comprehensive review. J. Ayu. Herb Med. 2021;7(3):193-200. https://doi.org/10.31254/jahm.2021.7305Asbury R.E., Saville B.A. Manno-oligosaccharides as a promising antimicrobial strategy: pathogen inhibition and synergistic effects with antibiotics. Front. Microbiol. 2025; 16:1529081. https://doi.org/10.3389/fmicb.2025.1529081Asbury R.E., Saville B.A. Manno-oligosaccharides as a promising antimicrobial strategy: pathogen inhibition and synergistic effects with antibiotics. Front. Microbiol. 2025;16:1529081. https://doi.org/10.3389/fmicb.2025.1529081Zhou M. Tao, Y. Lai, C. et al. Effects of mannanoligosaccharide supplementation on the growth performance, immunity, and oxidative status of partridge shank chickens // Animals. 2019;9:817. https://doi.org/10.3390/ani9100817Zhou M., Tao Y., Lai C. et al. Effects of mannanoligosaccharide supplementation on the growth performance, immunity, and oxidative status of partridge shank chickens. Animals. 2019;9:817. https://doi.org/10.3390/ani9100817Aruwa C.E., Pillay C., Nyaga M.M. et al. Poultry gut health – microbiome functions, environmental impacts, microbiome engineering and advancements in characterization technologies. J Animal Sci Biotechnol. 2021;12:119. https://doi.org/10.1186/s40104-021-00640-9Aruwa C.E., Pillay C., Nyaga M.M. et al. Poultry gut health – microbiome functions, environmental impacts, microbiome engineering and advancements in characterization technologies. J Animal Sci Biotechnol. 2021;12:119. https://doi.org/10.1186/s40104-021-00640-9Kuzmina I.V., Tolpygo S.M., Kotov A.V. et al. Intestinal digestion in poultry compared to other animal species with a diverse diet. Front. Physiol. 2024;15:1358524. https://doi.org/10.3389/fphys.2024.1358524Kuzmina I.V., Tolpygo S.M., Kotov A.V. et al. Intestinal digestion in poultry compared to other animal species with a diverse diet. Front. Physiol. 2024;15:1358524. https://doi.org/10.3389/fphys.2024.1358524Фисинин В.И., Егоров И.А., Манукян В.А. и др. Состояние микрофлоры желудочно-кишечного тракта кур-несушек при замене в комбикорме кукурузы пшеницей // Птица и птицепродукты. 2016. № 6. С. 33-36. EDN: XEPROL.Fisinin V.I., Egorov I.A., Manukyan V.A., Lenkova T.N. et al. State of the gastrointestinal tract microflora of laying hens when replacing corn with wheat in compound feed. Poultry & Chicken Products. 2016;(6):33-36. (In Russ.)Cai L., Indrakumar S., Kiarie E., Kim I.H. Effects of a multi-strain Bacillus species-based direct-fed microbial on growth performance, nutrient digestibility, blood profile, and gut health in nursery pigs fed corn-soybean meal-based diets. J Anim Sci. 2015;93:4336-4342. https://doi.org/10.2527/jas.2015-9056Cai L., Indrakumar S., Kiarie E., Kim I.H. Effects of a multi-strain Bacillus species-based direct-fed microbial on growth performance, nutrient digestibility, blood profile, and gut health in nursery pigs fed corn-soybean meal-based diets. J Anim Sci. 2015;93:4336-4342. https://doi.org/10.2527/jas.2015-9056Che L., Hu L., Liu Y. et al. Dietary nucleotides supplemen-tation improves the intestinal development and immune function of neonates with intra-uterine growth restriction in a pig model. PLoS ONE. 2016;11(6): e0157314. https://doi.org/10.1371/journal.pone.0157314Che L., Hu L., Liu Y. et al. Dietary nucleotides supplemen-tation improves the intestinal development and immune function of neonates with intra-uterine growth restriction in a pig model. PLoS ONE. 2016;11(6): e0157314. https://doi.org/10.1371/journal.pone.0157314Барило О.А., Берлинский Ю.Р., Мерзленко Р.А., Мингалеева Л.А. Актуальность использования пробиотиков и пребиотиков в животноводстве и ветеринарии // Актуальные вопросы сельскохозяйственной биологии. 2023. № 2 (28). С. 5-9. EDN: NQQYTGBarilo O.A., Berlinskiy Yu.R., Merzlenko R.A., Mingaleeva L.A. Relevance of the use of probiotics and prebiotics in animal husbandry and veterinary medicine. Actual Issues in Agricultural Biology. 2023;(2(28)):5-9. (In Russ.)Мурашов А.Г., Ермолова Е.М., Ермолов С.М. и др. Использование пробиотика в рационе свиноматок // Известия Оренбургского государственного аграрного университета. 2021. № 5. С. 234-238. https://doi.org/10.37670/2073-0853-2021-91-5-234-238Murashov A.G., Ermolova E.M., Ermolov S.M., Rebezov M.B. et al. Use of a probiotic in the diet of sows. Izvestiya Orenburgskogo gosudarstvennogo agrarnogo universiteta. 2021;(5):234-238. (In Russ.)Калоев Б.С. Влияние комплексного использования ферментного, пробиотического и пребиотического препаратов на мясные качества цыплят-бройлеров // Известия Горского государственного аграрного университета. 2021. Т. 58-2. С. 71-76. EDN: IWXDNAKaloev B.S. Influence of complex use of enzyme, probiotic and prebiotic preparations on broiler chickens’ meat qualities. Proceedings of Gorsky State Agrarian University. 2021;58-2:71-76. (In Russ.)Liu Y. Fatty acids, inflammation and intestinal health in pigs. J Animal Sci Biotechnol. 2015;6:41. https://doi.org/10.1186/s40104-015-0040-1Liu Y. Fatty acids, inflammation and intestinal health in pigs. J Animal Sci Biotechnol. 2015;6:41. https://doi.org/10.1186/s40104-015-0040-1Barba-Vidal E., Martín-Orúe S.M., Castillejos L. Practical aspects of the use of probiotics in pig production: A review. Livestock Science. 2019;223:84-96. http://doi.org/10.1016/j.livsci.2019.02.017Barba-Vidal E., Martín-Orúe S.M., Castillejos L. Practical aspects of the use of probiotics in pig production: A review. Livestock Science. 2019;223:84-96. http://doi.org/10.1016/j.livsci.2019.02.017Gan F., Chen X., Liao S.F. et al. Selenium-enriched probiotics improve antioxidant status, immune function, and selenoprotein gene expression of piglets raised under high ambient temperature. J Agric Food Chem. 2014;62:4502-4508. https://doi.org/10.1021/jf501065dGan F., Chen X., Liao S.F. et al. Selenium-enriched probiotics improve antioxidant status, immune function, and selenoprotein gene expression of piglets raised under high ambient temperature. J Agric Food Chem. 2014;62:4502-4508. https://doi.org/10.1021/jf501065dGiang H., Viet T., Ogle B. Effects of supplementation of probiotics on the performance, nutrient digestibility and faecal microflora in growing-finishing pigs. Asian Australas. J. Anim. Sci. 2011;24(5):655-661. http://doi.org/10.5713/ajas.2011.10238Giang H., Viet T., Ogle B. Effects of supplementation of probiotics on the performance, nutrient digestibility and faecal microflora in growing-finishing pigs. Asian Australas. J. Anim. Sci. 2011;24(5):655-661. http://doi.org/10.5713/ajas.2011.10238Giang H.H., Viet T.Q., Ogle B., Lindberg J.E. Growth performance, digestibility, gut environment and health status in weaned piglets fed a diet supplemented with a complex of lactic acid bacteria alone or in combination with Bacillus subtilis and Saccharomyces boulardii. Livest Sci. 2012;143(2-3):132-141. http://doi.org/10.1016/j.livsci.2011.09.003Giang H.H., Viet T.Q., Ogle B., Lindberg J.E. Growth performance, digestibility, gut environment and health status in weaned piglets fed a diet supplemented with a complex of lactic acid bacteria alone or in combination with Bacillus subtilis and Saccharomyces boulardii. Livest Sci. 2012;143(2-3):132-141. http://doi.org/10.1016/j.livsci.2011.09.003Забашта Н.Н., Головко Е.Н., Синельщикова И.А. Коррекция кишечного микробиоценоза моногастричных // Ученые записки Казанской государственной академии ветеринарной медицины им. Н.Э. Баумана. 2024. Т. 260, № 4. С. 98-104. https://doi.org/10.31588/2413_4201_1883_4_260_98Zabashta N.N., Golovko E.N., Sinelshchikova I.A. Correction of intestinal microbiocenosis in monogastrics. Uchenye zapiski Kazanskoy gosudarstvennoy akademii veterinarnoy meditsiny im. N.E. Baumana. 2024;260(40):98-104. (In Russ.) https://doi.org/10.31588/2413_4201_1883_4_260_98Заболоцкая Т.В., Панявина К.Д., Штауфен А.В. Взаимодействие дрожжевых глюкоманнанов с патогенными и пробиотическими бактериями in vitro // Международный научно-исследовательский журнал. 2024. № 12 (150). [Электронный ресурс]. URL: https://doi.org/10.60797/IRJ.2024.150.66 (дата обращения: 18.05.2025)Zabolotskaya T.V., Panyavina K.D., Shtaufen A.V. Interaction of yeast glucomannans with pathogenic and probiotic bacteria in vitro. International Research Journal. 2024;(12(150)). (In Russ.) https://doi.org/10.60797/IRJ.2024.150.66 URL: https://research-journal.org/archive/12-150-2024-december/10.60797/IRJ.2024.150.66 (accessed: May 18, 2025)Krishnamurthy H.K., Pereira M., Bosco J. et al. Gut commensals and their metabolites in health and disease. Front. Microbiol. 2023;14:1244293. https://doi.org/10.3389/fmicb.2023.1244293Krishnamurthy H.K., Pereira M., Bosco J. et al. Gut commensals and their metabolites in health and disease. Front. Microbiol. 2023;14:1244293. https://doi.org/10.3389/fmicb.2023.1244293Keimer B., Pieper R., Simon A., Zentek J. Effect of time and dietary supplementa-tion with processed yeasts (Kluyveromyces fragilis) on immunological parame-ters in weaned piglets. Anim Feed Sci Technol. 2018;245:136-146. http://doi.org/10.1016/j.anifeedsci.2018.09.008Keimer B., Pieper R., Simon A., Zentek J. Effect of time and dietary supplementa-tion with processed yeasts (Kluyveromyces fragilis) on immunological parame-ters in weaned piglets. Anim Feed Sci Technol. 2018;245:136-146. http://doi.org/10.1016/j.anifeedsci.2018.09.008Markowiak P., Śliżewska K. The role of probiotics, prebiotics and synbiotics in animal nutrition. Gut Pathog. 2018;10:21. https://doi.org/10.1186/s13099-018-0250-0Markowiak P., Śliżewska K. The role of probiotics, prebiotics and synbiotics in animal nutrition. Gut Pathog. 2018;10:21. https://doi.org/10.1186/s13099-018-0250-0Bermúdez-Humarán L.G., Chassaing B., Langella P. Exploring the interaction and impact of probiotic and commensal bacteria on vitamins, minerals and short chain fatty acids metabolism. Microb Cell Fact. 2024. Vol. 23, № 172. https://doi.org/10.1186/s12934-024-02449-3Bermúdez-Humarán L.G., Chassaing B., Langella P. Exploring the interaction and impact of probiotic and commensal bacteria on vitamins, minerals and short chain fatty acids metabolism. Microb Cell Fact. 2024;23:172. https://doi.org/10.1186/s12934-024-02449-3Wu Y., Zhen W., Geng Y. et al. Effects of dietary Enterococcus faeci-um NCIMB11181 supplementation on growth performance and cellular and humoral immune responses in broiler chickens. Poult Sci. 2019;98(1):150-163. http://doi.org/10.3382/ps/pey368Wu Y., Zhen W., Geng Y. et al. Effects of dietary Enterococcus faeci-um NCIMB11181 supplementation on growth performance and cellular and humoral immune responses in broiler chickens. Poult Sci. 2019;98(1):150-163. http://doi.org/10.3382/ps/pey368Wu Z., Yang K., Zhang A. et al. Effects of Lactobacil-lus acidophilus on the growth performance, immune response, and intestinal barrier function of broiler chickens challenged with Escherichia coli O157. Poult Sci. 2021;100(9):101323. https://doi.org/10.1016/j.psj.2021.101323Wu Z., Yang K., Zhang A. et al. Effects of Lactobacil-lus acidophilus on the growth performance, immune response, and intestinal barrier function of broiler chickens challenged with Escherichia coli O157. Poult Sci. 2021;100(9):101323. https://doi.org/10.1016/j.psj.2021.101323Готхалс Л., Горбакова А. Сравнительные характеристики бутиратов, применяемых в продуктивном животноводстве и птицеводстве // Комбикорма. 2014. № 5. С. 43-45. EDN: QFZXRUGotkhals L., Gorbakova A. Comparative characteristics of butyrates used in productive livestock and poultry farming. Kombikorma. 2014;(5):43-45. (In Russ.)Драчеловский О.В. Применение короткоцепочечных и среднецепочечных кислот в свиноводстве // IV Всебелорусский Форум животноводов. Минск: Издательский дом Гревцова, 2017. С. 137-144Drachelovskiy O.V. Application of short-chain and medium-chain acids in pig breeding. Chetveriy Vsebelorusskiy Forum Zhivodnovodov. Minsk, Belarus: Izdatelskiy dom Grevtsova, 2017:137-144. (In Russ.)Ленкова Т.Н., Трошкин А.Н., Драчеловский О.В. Применение бутирата натрия эффективно // Птицеводство. 2014. № 12. С. 21-26. EDN: TJZPBPLenkova T.N., Troshkin A.N., Drachelovskiy O.V. Use of sodium butyrate is effective. Ptitsevodstvo. 2014;(12):21-26. (In Russ.)Сизикова Т., Горбакова А. Источник масляной кислоты в интенсификации птицеводства // Комбикорма. 2014. № 7. С. 67-68. EDN: SIFONVSizikova T., Gorbakova A. Source of butyric acid in the intensification of poultry farming. Kombikorma. 2014;(7):67-68. (In Russ.)Hill C., Guarner F., Reid G. еt al. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014;11(8):506-514. https://doi.org/10.1038/nrgastro.2014.66Hill C., Guarner F., Reid G., Gibson G.R. et al. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014;11(8):506-514. https://doi.org/10.1038/nrgastro.2014.66Yirga H. The use of probiotics in animal nutrition. J Prob Health. 2015;3:132. https://doi.org/10.4172/2329-8901.1000132Yirga H. The use of probiotics in animal nutrition. J Prob Health. 2015;3:132. https://doi.org/10.4172/2329-8901.1000132Daudelin J.F., Lessard M., Beaudoin F. et al. Administration of probiotics influences F4 (K88)-positive enterotoxigenic Escherichia coli attachment and intestinal cytokine expression in weaned pigs. Vet Res 2011;42:69. https://doi.org/10.1186/1297-9716-42-69Daudelin J.F., Lessard M., Beaudoin F. et al. Administration of probiotics influences F4 (K88)-positive enterotoxigenic Escherichia coli attachment and intestinal cytokine expression in weaned pigs. Vet Res 2011;42:69. https://doi.org/10.1186/1297-9716-42-69Zhang Y., Zhang Y., Liu F. et al. Mechanisms and applications of probiotics in prevention and treatment of swine diseases. Porc Health Manag. 2023;9:5. https://doi.org/10.1186/s40813-022-00295-6Zhang Y., Zhang Y., Liu F. et al. Mechanisms and applications of probiotics in prevention and treatment of swine diseases. Porc Health Manag. 2023;9:5. https://doi.org/10.1186/s40813-022-00295-6Liao S.F., Nyachoti M. Using probiotics to improve swine gut health and nutrient utilization. Anim Nutr. 2017;3(4):331-343. https://doi.org/10.1016/j.aninu.2017.06.007Liao S.F., Nyachoti M. Using probiotics to improve swine gut health and nutrient utilization. Anim Nutr. 2017;3(4):331-343. https://doi.org/10.1016/j.aninu.2017.06.007Raheem A., Liang L., Zhang G., Cui S. Modulatory Effects of Probiotics During Pathogenic Infections With Emphasis on Immune Regulation. Front. Immunol. 2021; 12:616713. https://doi.org/10.3389/fimmu.2021.616713Raheem A., Liang L., Zhang G., Cui S. Modulatory Effects of Probiotics During Pathogenic Infections with Emphasis on Immune Regulation. Front. Immunol. 2021;12:616713. https://doi.org/10.3389/fimmu.2021.616713Wu T., Wang G., Xiong Z. et al. Probiotics Interact With Lipids Metabolism and Affect Gut Health. Front. Nutr. 2022;9:917043. https://doi.org/10.3389/fnut.2022.917043Wu T., Wang G., Xiong Z. et al. Probiotics Interact With Lipids Metabolism and Affect Gut Health. Front. Nutr. 2022;9:917043. https://doi.org/10.3389/fnut.2022.917043Varankovich N.V., Nickerson M.T., Korber D.R. Probiotic-based strategies for therapeutic and prophylactic use against multiple gastrointestinal diseases. Front. Microbiol. 2015;6:685. https://doi.org/10.3389/fmicb.2015.00685Varankovich N.V., Nickerson M.T., Korber D.R. Probiotic-based strategies for therapeutic and prophylactic use against multiple gastrointestinal diseases. Front. Microbiol. 2015;6:685. https://doi.org/10.3389/fmicb.2015.00685Reiners J., Lagedroste M., Ehlen K. et al. The N-terminal Region of Nisin Is Important for the BceAB-Type ABC Transporter NsrFP from Streptococcus agalactiae COH1. Front. Microbiol. 2017;8:1643. https://doi.org/10.3389/fmicb.2017.01643Reiners J., Lagedroste M., Ehlen K., Leusch S. et al. The N-terminal Region of Nisin Is Important for the BceAB-Type ABC Transporter NsrFP from Streptococcus agalactiae COH1. Front. Microbiol. 2017;8:1643. https://doi.org/10.3389/fmicb.2017.01643Szydłowska A., Sionek B. Probiotics and Postbiotics as the Functional Food Components Affecting the Immune Response. Microorganisms. 2023;11:104. https://doi.org/10.3390/microorganisms11010104Szydłowska A., Sionek B. Probiotics and Postbiotics as the Functional Food Components Affecting the Immune Response. Microorganisms. 2023;11:104. https://doi.org/10.3390/microorganisms11010104Hevia A., Delgado S., Sánchez B., Margolles A. Molecular Players Involved in the Interaction Between Beneficial Bacteria and the Immune System. Front. Microbiol. 2015;6:1285. https://doi.org/10.3389/fmicb.2015.01285Hevia A., Delgado S., Sánchez B., Margolles A. Molecular Players Involved in the Interaction Between Beneficial Bacteria and the Immune System. Front. Microbiol. 2015;6:1285. https://doi.org/10.3389/fmicb.2015.01285Motran C.C., Silvane L., Chiapello L.S. et al. Helminth Infections: Recognition and Modulation of the Immune Response by Innate Immune Cells. Front. Immunol. 2018;9:664. https://doi.org/10.3389/fimmu.2018.00664Motran C.C., Silvane L., Chiapello L.S. et al. Helminth Infections: Recognition and Modulation of the Immune Response by Innate Immune Cells. Front. Immunol. 2018;9:664. https://doi.org/10.3389/fimmu.2018.00664Vieco-Saiz N., Belguesmia Y., Raspoet R. et al. Benefits and Inputs From Lactic Acid Bacteria and Their Bacteriocins as Alternatives to Antibiotic Growth Promoters During Food-Animal Production. Front. Microbiol. 2019;10:57. https://doi.org/10.3389/fmicb.2019.00057Vieco-Saiz N., Belguesmia Y., Raspoet R., Auclair E. et al. Benefits and Inputs From Lactic Acid Bacteria and Their Bacteriocins as Alternatives to Antibiotic Growth Promoters During Food-Animal Production. Front. Microbiol. 2019;10:57. https://doi.org/10.3389/fmicb.2019.00057Rastogi S., Singh A. Gut microbiome and human health: Exploring how the probiotic genus Lactobacillus modulate immune responses. Front. Pharmacol. 2022;13:1042189. https://doi.org/10.3389/fphar.2022.1042189Rastogi S., Singh A. Gut microbiome and human health: Exploring how the probiotic genus Lactobacillus modulate immune responses. Front. Pharmacol. 2022;13:1042189. https://doi.org/10.3389/fphar.2022.1042189Soares A., Beraldi E.J., Ferreira P.E.B. et al. Intestinal and neuronal myenteric adaptations in the small intestine induced by a high-fat diet in mice. BMC Gastroenterol. 2015;15:3. https://doi.org/10.1186/s12876-015-0228-zSoares A., Beraldi E.J., Ferreira P.E.B., Bazotte R.B. et al. Intestinal and neuronal myenteric adaptations in the small intestine induced by a high-fat diet in mice. BMC Gastroenterol. 2015;15:3. https://doi.org/10.1186/s12876-015-0228-zMohamed T.M., Sun W., Bumbie G.Z. et al. Feeding Bacillus subtilis ATCC19659 to broiler chickens enhances growth performance and immune function by modulating intestinal morphology and cecum microbiota. Front Microbiol. 2022;12:798350. https://doi.org/10.3389/fmicb.2021.798350Mohamed T.M., Sun W., Bumbie G.Z., Elokil A.A. et al. Feeding Bacillus subtilis ATCC19659 to broiler chickens enhances growth performance and immune function by modulating intestinal morphology and cecum microbiota. Front Microbiol. 2022;12:798350. https://doi.org/10.3389/fmicb.2021.798350Kaminsky L.W., Al-Sadi R., Ma T.Y. IL-1β and the intestinal epithelial tight junction barrier. Front. Immunol. 2021;12:767456. https://doi.org/10.3389/fimmu.2021.767456Kaminsky L.W., Al-Sadi R., Ma T.Y. IL-1β and the intestinal epithelial tight junction barrier. Front. Immunol. 2021;12:767456. https://doi.org/10.3389/fimmu.2021.767456Kim K., Song M., Liu Y., Ji P. Enterotoxigenic Escherichia coli infection of weaned pigs: Intestinal challenges and nutritional intervention to enhance disease resistance. Front. Immunol. 2022;13:885253. https://doi.org/10.3389/fimmu.2022.885253Kim K., Song M., Liu Y., Ji P. Enterotoxigenic Escherichia coli infection of weaned pigs: Intestinal challenges and nutritional intervention to enhance disease resistance. Front. Immunol. 2022;13:885253. https://doi.org/10.3389/fimmu.2022.885253Mazur-Kuśnirek M., Lipiński K., Antoszkiewicz Z., Matusevičius P. Different forms of butyric acid in poultry nutrition – a review. Journal of Animal and Feed Sciences. 2024;33(3):270-280. https://doi.org/10.22358/jafs/186022/2024Mazur-Kuśnirek M., Lipiński K., Antoszkiewicz Z., Matusevičius P. Different forms of butyric acid in poultry nutrition – a review. Journal of Animal and Feed Sciences. 2024;33(3):270-280. https://doi.org/10.22358/jafs/186022/2024

The authors declare that there are no conflicts of interest present.